| Day | Date | Opponent | Location | Outcome |
| SAT | 8/14/10 | Holt Invitational Shootout | HOME - Holt High School Stadium | 6:30 PM |  |
| SAT | 8/21/10 | Portage Central @ Portage Invite | Portage Soccer Complex | W, 2-1 | |
| SAT | 8/21/10 | East Kentwood @ Portage Invite | Portage Soccer Complex | L, 0-5 | |
| SAT | 8/21/10 | Forest Hills Central @ Portage Invite | Portage Soccer Complex | T, 1-1 | |
| TUE | 8/24/10 | Ann Arbor Huron | HOME - Holt High School Stadium | T, 1-1 | |
| SAT | 8/28/10 | Livonia Churchill @ De La Salle Invite | Ultimate Soccer | W, 3-1 | |
| SAT | 8/28/10 | Rockford @ De La Salle Invite | Ultimate Soccer | T, 1-1 | |
| SAT | 8/28/10 | De La Salle (Champ Game) @ De La Salle Invite | Ultimate Soccer | T, 0-0 | |
| WED | 9/1/10 | Caledonia | Caledonia Duncan Lake Middle School | W, 6-0 | |
| THU | 9/9/10 | Lumen Christi | HOME - Holt High School Stadium | W, 8-0 | |
| SAT | 9/11/10 | Grandville | HOME - Holt High School Stadium | W, 2-0 | |
| MON | 9/13/10 | East Lansing | HOME - Holt High School Stadium | W, 5-0 | |
| WED | 9/15/10 | Jackson | Jackson - Mehall Field | W, 2-0 | |
| SAT | 9/18/10 | Midland Dow | Midland Dow - Soccer Stadium | T, 2-2 | |
| MON | 9/20/10 | Lansing Eastern | HOME - Holt High School Stadium | W, 3-0 | |
| WED | 9/22/10 | Lansing Everett | Everett - High School Soccer Stadium | W, 4-0 | |
| SAT | 9/25/10 | Haslett | HOME - Holt High School Stadium | W, 3-0 | |
| MON | 9/27/10 | Okemos | HOME - Holt High School Stadium | W, 1-0 | |
| WED | 9/29/10 | Grand Ledge | Grand Ledge - Sports Stadium | W, 2-1 | |
| SAT | 10/2/10 | Dexter | HOME - Holt High School Stadium | T, 2-2 | |
| THU | 10/7/10 | Charlotte - CAAC Gold Cup | HOME - Holt High School Stadium | W, 5-0 | |
| TUE | 10/12/10 | Dewitt - CAAC Gold Cup | HOME - Holt High School Stadium | L, 1-4 | |
| THU | 10/14/10 | Lansing Catholic Central - CAAC Gold Cup | Lansing Catholic Central - Soccer Stadium | W, 3-1 | |
| TUE | 10/19/10 | Districts - Portage Northern | Portage Northern Huskie Field | W, 2-0 | |
| THU | 10/21/10 | Districts - Battle Creek Lakeview | Portage Northern Huskie Field | L, 3-4 | |
